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Article Dans Une Revue European Journal of Clinical Microbiology and Infectious Diseases Année : 2022

Capnocytophaga zoonotic infections: a 10-year retrospective study (the French CANCAN study)

Tristan Diedrich
  • Fonction : Auteur
Caroline Piau
  • Fonction : Auteur
Eric Farfour
Lucas Bonzon
  • Fonction : Auteur
Cécile Le Brun
Violaine Walewski
  • Fonction : Auteur
Emmanuelle Bille
Laurent Dortet
Nathalie Soismier
  • Fonction : Auteur
Ronan Le Guen
  • Fonction : Auteur
Philippe Morand
  • Fonction : Auteur
Gauthier Péan de Ponfilly

Résumé

Zoonotic species of Capnocytophaga genus belong to the oral microbiota of dogs and cats. They may be responsible for serious human infections, mainly after animal bites, with a high mortality rate. In France, only few cases have been reported and no multicenter study has been conducted. Our aim was to describe the French epidemiology of Capnocytophaga zoonosis. We conducted a multicenter (21 centers) retrospective non-interventional, observational study in France describing the epidemiology of Capnocytophaga zoonosis (C. canimorsus, C. cynodegmi, C. canis) over 10 years with regard to clinical and bacteriological data. From 2009 to 2018, 44 cases of Capnocytophaga zoonotic infections were described (C. canimorsus, n = 41; C. cynodegmi, n = 3). We observed an increase (2.5 times) in the number of cases over the study period (from the first to the last 5 years of the study). The most frequent clinical presentations were sepsis (n = 37), skin and soft tissue infections (n = 12), meningitis (n = 8), osteoarticular infections (n = 6), and endocarditis (n = 2). About one-third of patients with sepsis went into septic shock. Mortality rate was 11%. Mortality and meningitis rates were significantly higher for alcoholic patients (p = 0.044 and p = 0.006, respectively). Other comorbidities included smoking, splenectomy, diabetes mellitus, and immunosuppressive therapy are associated to zoonotic Capnocytophaga infection. Eighty-two percent of cases involved contact with dogs, mostly included bites (63%). Despite all isolates were susceptible to the amoxicillin-clavulanic acid combination, three of them were resistant to amoxicillin.
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Dates et versions

hal-03624206 , version 1 (30-03-2022)

Identifiants

Citer

Clémence Beauruelle, Chloé Plouzeau, Antoine Grillon, Christophe Isnard, Stéphane Corvec, et al.. Capnocytophaga zoonotic infections: a 10-year retrospective study (the French CANCAN study). European Journal of Clinical Microbiology and Infectious Diseases, 2022, 41 (4), pp 581-588. ⟨10.1007/s10096-022-04402-x⟩. ⟨hal-03624206⟩
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