SN- and NS-puckered sugar conformers are precursors of the (6–4) photoproduct in thymine dinucleotide

Jouda Jakhlal; Clément Denhez; Stéphanie Coantic-Castex; Agathe Martinez; Dominique Harakat; Thierry Douki; Dominique Guillaume; Pascale Clivio

doi:10.1039/d2ob00044j

Journal articles

SN- and NS-puckered sugar conformers are precursors of the (6–4) photoproduct in thymine dinucleotide

Jouda Jakhlal ¹ Clément Denhez ¹ Stéphanie Coantic-Castex ¹ Agathe Martinez ¹ Dominique Harakat ¹ Thierry Douki ² Dominique Guillaume ¹ Pascale Clivio ¹

1 ICMR - Institut de Chimie Moléculaire de Reims - UMR 7312

2 IRIG - Institut de Recherche Interdisciplinaire de Grenoble

Abstract : The S conformation of at least one sugar residue in the TT site is crucial for (6–4) PP formation. This S sugar can be located at the 5′- or 3′-end of the TT site. The 5′-end S conformer location is the most efficient at providing (6–4) PP.

Document type :

Journal articles

Domain :

Chemical Sciences / Organic chemistry

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https://hal.univ-reims.fr/hal-03624902
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Submitted on : Wednesday, March 30, 2022 - 3:24:06 PM
Last modification on : Friday, April 1, 2022 - 3:24:51 AM

SN- and NS-puckered sugar conformers are precursors of the (6–4) photoproduct in thymine dinucleotide

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SN- and NS-puckered sugar conformers are precursors of the (6–4) photoproduct in thymine dinucleotide

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