Skip to Main content Skip to Navigation
Journal articles

Mechanistic Insights into the Pharmacological Significance of Silymarin

Abstract : Medicinal plants are considered the reservoir of diverse therapeutic agents and have been traditionally employed worldwide to heal various ailments for several decades. Silymarin is a plant-derived mixture of polyphenolic flavonoids originating from the fruits and akenes of Silybum marianum and contains three flavonolignans, silibinins (silybins), silychristin and silydianin, along with taxifolin. Silybins are the major constituents in silymarin with almost 70–80% abundance and are accountable for most of the observed therapeutic activity. Silymarin has also been acknowledged from the ancient period and is utilized in European and Asian systems of traditional medicine for treating various liver disorders. The contemporary literature reveals that silymarin is employed significantly as a neuroprotective, hepatoprotective, cardioprotective, antioxidant, anti-cancer, anti-diabetic, anti-viral, anti-hypertensive, immunomodulator, anti-inflammatory, photoprotective and detoxification agent by targeting various cellular and molecular pathways, including MAPK, mTOR, β-catenin and Akt, different receptors and growth factors, as well as inhibiting numerous enzymes and the gene expression of several apoptotic proteins and inflammatory cytokines. Therefore, the current review aims to recapitulate and update the existing knowledge regarding the pharmacological potential of silymarin as evidenced by vast cellular, animal, and clinical studies, with a particular emphasis on its mechanisms of action.
Document type :
Journal articles
Complete list of metadata

https://hal.univ-reims.fr/hal-03756357
Contributor : ISABELLE ROBERRINI Connect in order to contact the contributor
Submitted on : Monday, August 22, 2022 - 12:23:01 PM
Last modification on : Tuesday, August 23, 2022 - 4:01:54 AM

File

molecules-27-05327.pdf
Publisher files allowed on an open archive

Licence


Distributed under a Creative Commons Attribution 4.0 International License

Identifiers

Collections

Citation

Karan Wadhwa, Rakesh Pahwa, Manish Kumar, Shobhit Kumar, Prabodh Chander Sharma, et al.. Mechanistic Insights into the Pharmacological Significance of Silymarin. Molecules, MDPI, 2022, 27 (16), pp.5327. ⟨10.3390/molecules27165327⟩. ⟨hal-03756357⟩

Share

Metrics

Record views

5

Files downloads

2