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Journal Articles NPJ Regenerative medicine Year : 2022

Regulation of stem cell fate by HSPGs: implication in hair follicle cycling

Abstract

Abstract Heparan sulfate proteoglycans (HSPGs) are part of proteoglycan family. They are composed of heparan sulfate (HS)-type glycosaminoglycan (GAG) chains covalently linked to a core protein. By interacting with growth factors and/or receptors, they regulate numerous pathways including Wnt, hedgehog (Hh), bone morphogenic protein (BMP) and fibroblast growth factor (FGF) pathways. They act as inhibitor or activator of these pathways to modulate embryonic and adult stem cell fate during organ morphogenesis, regeneration and homeostasis. This review summarizes the knowledge on HSPG structure and classification and explores several signaling pathways regulated by HSPGs in stem cell fate. A specific focus on hair follicle stem cell fate and the possibility to target HSPGs in order to tackle hair loss are discussed in more dermatological and cosmeceutical perspectives.
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Dates and versions

hal-03946375 , version 1 (19-01-2023)

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Charlie Colin-Pierre, Oussama El Baraka, Louis Danoux, Vincent Bardey, Valérie André, et al.. Regulation of stem cell fate by HSPGs: implication in hair follicle cycling. NPJ Regenerative medicine, 2022, 7 (1), pp.77. ⟨10.1038/s41536-022-00267-y⟩. ⟨hal-03946375⟩

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