Production of high molecular-ordered stilbene oligomers for the study of their biological activity: total synthesis, bio-catalyzed synthesis and production by plant systems - Université de Reims Champagne-Ardenne Access content directly
Journal Articles Natural Product Reports Year : 2023

Production of high molecular-ordered stilbene oligomers for the study of their biological activity: total synthesis, bio-catalyzed synthesis and production by plant systems

Production of high molecular-ordered stilbene oligomers for the study of their biological activity: total synthesis

Md. Sahab Uddin
Haroon Khan
Muhammad Ajmal Shah
Mattheos Koffas
  • Function : Author
Seyed Mohammad Nabavi
Eduardo Sobarzo-Sánchez
  • Function : Author
Jean-Hugues Renault
  • Function : Author

Abstract

Though the iconic stilbene resveratrol and its related dimers constitute a top storyline in the field of natural product research, resveratrol oligomers (condensation >2) have been left aside despite their higher biological activity compared to that of the monomers. This situation largely results from the difficulty of getting them in sufficient quantities to enable evaluation of their biological properties in vivo. We present here a synthetic and critical analysis of the methods used for the production of high molecular-ordered stilbene oligomers of potential biomedical interest, gathering the most salient data regarding the approaches employed to prepare them by total synthesis, use of biomimetic approaches or through plant systems.
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Dates and versions

hal-04064283 , version 1 (11-04-2023)

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Philippe Jeandet, Md. Sahab Uddin, Christophe Clément, Aziz Aziz, Cédric Jacquard, et al.. Production of high molecular-ordered stilbene oligomers for the study of their biological activity: total synthesis, bio-catalyzed synthesis and production by plant systems. Natural Product Reports, 2023, ⟨10.1039/D2NP00073C⟩. ⟨hal-04064283⟩
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