Lympho-hematopoietic malignancies risk after exposure to low dose ionizing radiation during cardiac catheterization in childhood - Université de Reims Champagne-Ardenne Access content directly
Journal Articles European Journal of Epidemiology Year : 2023

Lympho-hematopoietic malignancies risk after exposure to low dose ionizing radiation during cardiac catheterization in childhood

Kossi Abalo
  • Function : Author
Sophie Malekzadeh-Milani
  • Function : Author
Sébastien Hascoët
  • Function : Author
Serge Dreuil
  • Function : Author
Tiphaine Feuillet
  • Function : Author
Cecilia Damon
  • Function : Author
Hélène Bouvaist
  • Function : Author
Ivan Bouzguenda
  • Function : Author
Sarah Cohen
  • Function : Author
Claire Dauphin
  • Function : Author
Sylvie Di Filippo
  • Function : Author
Stéphanie Douchin
  • Function : Author
François Godart
  • Function : Author
Patrice Guérin
  • Function : Author
Pauline Helms
  • Function : Author
Clément Karsenty
  • Function : Author
Bruno Lefort
  • Function : Author
Caroline Ovaert
  • Function : Author
Jean-François Piéchaud
  • Function : Author
Jean-Benoît Thambo
  • Function : Author
Choonsik Lee
  • Function : Author
Mark Little
  • Function : Author
Damien Bonnet
  • Function : Author
Marie-Odile Bernier
  • Function : Author

Abstract

Pediatric patients with congenital heart disease (CHD) often undergo low dose ionizing radiation (LDIR) from cardiac catheterization (CC) for the diagnosis and/or treatment of their disease. Although radiation doses from a single CC are usually low, less is known about the long-term radiation associated cancer risks. We aimed to assess the risk of lympho-hematopoietic malignancies in pediatric CHD patients diagnosed or treated with CC. A French cohort of 17,104 children free of cancer who had undergone a first CC from 01/01/2000 to 31/12/2013, before the age of 16 was set up. The follow-up started at the date of the first recorded CC until the exit date, i.e., the date of death, the date of first cancer diagnosis, the date of the 18th birthday, or the 31/12/2015, whichever occurred first. Poisson regression was used to estimate the LDIR associated cancer risk. The median follow-up was 5.9 years, with 110,335 person-years. There were 22,227 CC procedures, yielding an individual active bone marrow (ABM) mean cumulative dose of 3.0 milligray (mGy). Thirty-eight incident lympho-hematopoietic malignancies were observed. When adjusting for attained age, gender and predisposing factors to cancer status, no increased risk was observed for lympho-hematopoietic malignancies RR/mGy = 1.00 (95% CI: 0.88; 1.10). In summary, the risk of lympho-hematopoietic malignancies and lymphoma was not associated to LDIR in pediatric patients with CHD who undergo CC. Further epidemiological studies with greater statistical power are needed to improve the assessment of the dose-risk relationship.
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Dates and versions

hal-04179084 , version 1 (09-08-2023)

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Kossi Abalo, Sophie Malekzadeh-Milani, Sébastien Hascoët, Serge Dreuil, Tiphaine Feuillet, et al.. Lympho-hematopoietic malignancies risk after exposure to low dose ionizing radiation during cardiac catheterization in childhood. European Journal of Epidemiology, 2023, 38 (7), pp.821-834. ⟨10.1007/s10654-023-01010-7⟩. ⟨hal-04179084⟩
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