Epithelial–mesenchymal plasticity and circulating tumor cells: Travel companions to metastases - Université de Reims Champagne-Ardenne Access content directly
Journal Articles Developmental Dynamics Year : 2017

Epithelial–mesenchymal plasticity and circulating tumor cells: Travel companions to metastases

Marie‐emilie Francart
  • Function : Author
Justine Lambert
  • Function : Author
Aline Vanwynsberghe
  • Function : Author
Erik Thompson
  • Function : Author
Morgane Bourcy
  • Function : Author
Christine Gilles

Abstract

Epithelial–mesenchymal transitions (EMTs) associated with metastatic progression may contribute to the generation of hybrid phenotypes capable of plasticity. This cellular plasticity would provide tumor cells with an increased potential to adapt to the different microenvironments encountered during metastatic spread. Understanding how EMT may functionally equip circulating tumor cells (CTCs) with an enhanced competence to survive in the bloodstream and niche in the colonized organs has thus become a major cancer research axis. We summarize here clinical data with CTC endpoints involving EMT. We then review the work functionally linking EMT programs to CTC biology and deciphering molecular EMT‐driven mechanisms supporting their metastatic competence. Developmental Dynamics 247:432–450, 2018 . © 2017 Wiley Periodicals, Inc.

Dates and versions

hal-04472511 , version 1 (22-02-2024)

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Marie‐emilie Francart, Justine Lambert, Aline Vanwynsberghe, Erik Thompson, Morgane Bourcy, et al.. Epithelial–mesenchymal plasticity and circulating tumor cells: Travel companions to metastases. Developmental Dynamics, 2017, 247 (3), pp.432-450. ⟨10.1002/dvdy.24506⟩. ⟨hal-04472511⟩

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