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European research laboratory for rheumatoid arthritis - GenHotel is a research unit of University of Evry since 1999 on the Genopole campus. For nearly 20 years, our lab has focused on the aetiology of a complex disease, rheumatoid arthritis (RA). After a period consisted of 'classical' genetic analyses through linkage and association studies, results, and particularly GWAS one, lead us to develop alternative approaches. Instead of considering common genomic variants, we decided to focus on rare and specific ones, to identify biomarkers in RA and its phenotypes. In this direction, we developed a global approach to the disease by mapping all the connections. Based on these approaches, our research activity is divided into two main axis: Characterization of new RA genomic variants and Computational systems biology approaches for the construction of graphical and dynamical models of disease mechanisms to study their complex dynamic behavior. Results of the first axis feed the second project, contributing to the development of a pipeline for identifying new lines in RA drug design.

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Databases African Continental Ancestry Group Autoimmune thyroid disease Shared Epitope Animals Genetic Linkage Arthritis Biomarkers Family Health Breast cancer Humans HLA-DR Antigens Age Factors Antirheumatic Agents Metabolic reprogramming Genotype HLA-DRB1 Ankylosing Phenotype In silico simulations Rheumatoid Factor Boolean models HLA-DRB1 Chains APOPTOSIS Genetic Predisposition to Disease Adolescent Single Nucleotide Génétique Biologie computationnelle des systèmes Male RHEUMATOID ARTHRITIS Logical modelling Algerian population Autoimmune thyroid diseases PTPN22 gene Computational systems biology Female Boolean simulations ASSOCIATION STUDY Binding Sites Antigen Presentation Tunisia Case-Control Studies Genetic Network inference Complex genetic disease Protein Tyrosine Phosphatase Rheumatoid arthritis Biological pathway Europe 80 and over Autoimmunity Antigens Autoantibodies Linkage Disequilibrium Haplotypes Adult Ankylosing spondylitis Family Rheumatoid Arthritis Reproducibility Boolean networks Autoantibody Production Annotation standards ATP Binding Cassette Transporter C-Type France Polyarthrite rhumatoïde Genetic Association Studies Disease maps ABCB1 Algeria Environment Anti-citrullinated protein antibodies Rheumatoid Alleles Middle Aged Risk Factors Cohort Studies Genetics Analysis Systems biology Biocuration Aged Non-Receptor Type 22 Odds Ratio Biologie des systèmes European Continental Ancestry Group Antibodies Association study POLYMORPHISM Age of Onset Gene Frequency Receptors Young Adult Rheumatoid Arthritis Patient Polymorphism Anti-Idiotypic Autoimmune Diseases Epitopes

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