Bile acids regulate MAdCAM-1 expression to link the gut microbiota to cancer immunosurveillance - Université de Paris - Faculté de Santé Access content directly
Journal Articles OncoImmunology Year : 2023

Bile acids regulate MAdCAM-1 expression to link the gut microbiota to cancer immunosurveillance

Abstract

In a recent paper in Science, Fidelle et al. unravel a gut immune checkpoint that is subverted by antibiotic treatment. Post-antibiotic dysbiosis of the ileum causes an increase in bile acids that downregulate MAdCAM−1, thereby triggering the exodus of immunosuppressive T cells from gutassociated lymphoid tissues toward tumors.
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Dates and versions

hal-04154967 , version 1 (07-07-2023)

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Marine Fidelle, Ai-Ling Tian, Laurence Zitvogel, Guido Kroemer. Bile acids regulate MAdCAM-1 expression to link the gut microbiota to cancer immunosurveillance. OncoImmunology, 2023, 12 (1), ⟨10.1080/2162402X.2023.2224672⟩. ⟨hal-04154967⟩
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