Isolation and characterisation of cytotoxic compounds from Euphorbia clementei Boiss.

A new phorbol-type diterpene ester, 4,20-dideoxy-4α-phorbol-12β-acetate-13α-isobutyrate, in addition to 11 known compounds were isolated from the latex and roots of Euphorbia clementei Boiss. Structure elucidation was performed by comprehensive 1D and 2D NMR analyses (1H and 13C NMR, COSY, ROESY, HSQC and HMBC experiments), mass spectrometry (HR-ESI-MS) and by comparison with literature data. The inhibitory activity of all isolated compounds was evaluated against promyelocytic leukemia HL60 and human erythromyeloblastoid leukemia K562 cell lines and seven of these compounds exhibited a weak cytotoxicity with IC50 values ranging from 40 to 97 μM.

Keywords

Euphorbia clementei Euphorbiaceae diterpenoids triterpenoids cytotoxic activity

Domains

Chemical Sciences

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Isolation and characterization of cytotoxic compounds from Euphorbia clementei Boiss..pdf (275.71 Ko)

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Abdulmagid Alabdul Magid : Connect in order to contact the contributor

https://hal.univ-reims.fr/hal-01834095

Submitted on : Friday, November 5, 2021-2:08:06 PM

Last modification on : Monday, April 22, 2024-9:38:04 AM

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Dates and versions

hal-01834095 , version 1 (05-11-2021)

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HAL Id : hal-01834095 , version 1
DOI : 10.1080/14786419.2016.1277345

Cite

Abbes Benmerache, Abdulmagid Alabdul Magid, Amira Labed, Ahmed Kabouche, Laurence Voutquenne-Nazabadioko, et al.. Isolation and characterisation of cytotoxic compounds from Euphorbia clementei Boiss.. Natural Product Research, 2017, 31 (18), pp.2091 - 2098. ⟨10.1080/14786419.2016.1277345⟩. ⟨hal-01834095⟩

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