Isolation and characterisation of cytotoxic compounds from Euphorbia clementei Boiss.

Abbes Benmerache 1, 2 Abdulmagid Alabdul Magid 2 Amira Labed 1 Ahmed Kabouche 1 Laurence Voutquenne-Nazabadioko 2 Jane Hubert 2 Hamid Morjani 3 Zahia Kabouche 1
1 UMC - Université Mentouri Constantine [Algérie]
2 ICMR - Institut de Chimie Moléculaire de Reims - UMR 7312
3 MEDyC - Matrice extracellulaire et dynamique cellulaire - UMR 7369
Abstract : A new phorbol-type diterpene ester, 4,20-dideoxy-4α-phorbol-12β-acetate-13α-isobutyrate, in addition to 11 known compounds were isolated from the latex and roots of Euphorbia clementei Boiss. Structure elucidation was performed by comprehensive 1D and 2D NMR analyses (1H and 13C NMR, COSY, ROESY, HSQC and HMBC experiments), mass spectrometry (HR-ESI-MS) and by comparison with literature data. The inhibitory activity of all isolated compounds was evaluated against promyelocytic leukemia HL60 and human erythromyeloblastoid leukemia K562 cell lines and seven of these compounds exhibited a weak cytotoxicity with IC50 values ranging from 40 to 97 μM.
Keywords : Euphorbia clementei Euphorbiaceae diterpenoids triterpenoids cytotoxic activity
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Journal articles
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https://hal.univ-reims.fr/hal-01834095
Contributor : Abdulmagid Alabdul Magid <>
Submitted on : Tuesday, July 10, 2018 - 11:18:17 AM
Last modification on : Wednesday, December 18, 2019 - 1:26:34 AM

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Abbes Benmerache, Abdulmagid Alabdul Magid, Amira Labed, Ahmed Kabouche, Laurence Voutquenne-Nazabadioko, et al.. Isolation and characterisation of cytotoxic compounds from Euphorbia clementei Boiss.. Natural Product Research, Taylor & Francis, 2017, 31 (18), pp.2091 - 2098. ⟨10.1080/14786419.2016.1277345⟩. ⟨hal-01834095⟩

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