Triterpenoid saponins from Scabiosa stellata collected in North-eastern Algeria

Meryem Lehbili 1, 2 Abdulmagid Alabdul Magid 2 Ahmed Kabouche 1 Laurence Voutquenne-Nazabadioko 2 Hamid Morjani 3 Dominique Harakat 2 Zahia Kabouche 1
1 UMC - Université Mentouri Constantine [Algérie]
2 ICMR - Institut de Chimie Moléculaire de Reims - UMR 7312
3 MEDyC - Matrice extracellulaire et dynamique cellulaire - UMR 7369
Abstract : Eight undescribed triterpenoid saponins, scabiostellatosides A-H, together with three known compounds were isolated from the whole plant of Scabiosa stellata L. Their structures were established by spectroscopic analyses (1D, 2D-NMR and HRESIMS) and chemical methods. Scabiostellatosides A-H were evaluated for their cytotoxicity against human fibrosarcoma cell line (HT1080). Scabiostellatoside F, a heptasaccharide derivative of oleanolic acid, exhibited moderate cytotoxicity against HT1080 cell line with IC50 value of 12.0 μM.
Keywords : Scabiosa stellata L.Caprifoliaceae Triterpenoid saponins Cytotoxic activity
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Journal articles
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https://hal.univ-reims.fr/hal-01834154
Contributor : Abdulmagid Alabdul Magid <>
Submitted on : Tuesday, July 10, 2018 - 11:42:39 AM
Last modification on : Wednesday, December 18, 2019 - 1:26:34 AM

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URCA | CNRS | ICMR | INC-CNRS | CAPSANTE | SFRCONDORCET | BIOSPECT | MEDYC

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Meryem Lehbili, Abdulmagid Alabdul Magid, Ahmed Kabouche, Laurence Voutquenne-Nazabadioko, Hamid Morjani, et al.. Triterpenoid saponins from Scabiosa stellata collected in North-eastern Algeria. Phytochemistry, Elsevier, 2018, 150, pp.40 - 49. ⟨10.1016/j.phytochem.2018.03.005⟩. ⟨hal-01834154⟩

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