Serious games have taken up an important place in the field of health. The aim of this work was to design and to develop a serious game for students in Dental Education. The interest is to perform a multidisciplinary approach of patients. Several clinical cases are available online and each of them concerns patients treated by students in Dental Hospitals. After choosing the e-patient, the serious gamer progresses in the game step by step. The game-play simulates the similar methodology as a dental practitioner in clinical reality. E-learners have to make a diagnosis in a limited time. Finally, the goal is to treat the e-patient deciding the ideal treatment plan. The collaborative network between students and teacher(s) achieves an interactive learning and improves the quality of undergraduate Dental Education. The perspective is to promulgate dental education and to train young practitioners giving better dental care to patients after dental studies.