Triterpenoid saponins and other glycosides from the stems and bark of Jaffrea xerocarpa and their biological activity - Université de Reims Champagne-Ardenne Access content directly
Journal Articles Phytochemistry Year : 2017

Triterpenoid saponins and other glycosides from the stems and bark of Jaffrea xerocarpa and their biological activity

Abstract

Six previously undescribed triterpenoid saponins and two previously undescribed norlupane triterpenes were isolated with five known saponins, three known lupane derivatives, 17,20-didehydro-20-deoxyjujubogenin, rutin, (±) 3α-O-β-d-glucopyranosyl-lyoniresinol, (±) 4-O-β-d-glucopyranosyl-maesopsin, three phenol glycosides, and uridine from the stems and bark of Jaffrea xerocarpa (Baill.) H. C. Hopkins & Pillon (= Basionym Alphitonia xerocarpus Baill.) (Rhamnaceae), an endemic tree of New Caledonia. The chemical structures of the purified compounds were identified by nuclear magnetic resonance and mass spectrometry. The isolated compounds were tested for their antioxidant, antityrosinase, antibacterial and cytotoxic activities. The aqueous methanol extract showed antioxidant activity (DPPH assay) due to the presence of rutin and other phenolic compounds. Three lupane triterpenes showed good cytotoxic activities against KB cells line (IC50 from 7.7 to 8.5 μM). The previously undescribed 2α-formyl-A(1)norlup-20(29)-en-28-oic acid showed antibacterial activity against Staphylococcus aureus and Enterococcus faecalis with both MIC values of 4 μg/mL.
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hal-01996283 , version 1 (28-10-2021)

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Dima Muhammad, Nathalie Lalun, Hélène Bobichon, Elisabeth Le Magrex Debar, Sophie C. Gangloff, et al.. Triterpenoid saponins and other glycosides from the stems and bark of Jaffrea xerocarpa and their biological activity. Phytochemistry, 2017, 141, pp.121-130. ⟨10.1016/j.phytochem.2017.05.018⟩. ⟨hal-01996283⟩
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