A new δ-tocotrienolic acid derivative and other constituents from the cones of Cedrus atlantica and their in vitro antimicrobial activity - Archive ouverte HAL Access content directly
Journal Articles Phytochemistry Letters Year : 2017

A new δ-tocotrienolic acid derivative and other constituents from the cones of Cedrus atlantica and their in vitro antimicrobial activity

(1) , (2, 3) , (3) , (1) , (1) , (2)
1
2
3

Abstract

The phytochemical and antimicrobial properties of the cones of Cedrus atlantica (Endl) Manetti ex Carrière were investigated. Two new compounds (1,2) and nineteen known compounds (3–21) were isolated. Their structures were established by mass spectrometry (HRESIMS), 1D, 2D NMR and by comparison with literature data. Antimicrobial activity of hydromethanolic extract against a panel of 22 bacteria and yeasts showed an interesting antimicrobial activity. All compound purified from this extract were tested against S. aureus by bioautography. MIC values of the most active compounds were determined using a serial dilution technique. The results showed strong antibacterial activity of the abietane diterpenes 10, 11, 14, 15, 16 and 17. Dehydroabietic acid (17) was the most potent against Enterococcus faecalis (MIC = 15.1 = μg/mL), a multi-resistant commensal bacterium which can cause the fatal infections in humans.
Fichier principal
Vignette du fichier
Phytochemestry Letters publi Cedrus Revised_HAL.pdf (782.16 Ko) Télécharger le fichier
Origin : Files produced by the author(s)

Dates and versions

hal-01996289 , version 1 (28-10-2021)

Identifiers

Cite

Maya Belhadj Mostefa, Amin Abedini, Sophie C. Gangloff, Ahmed Kabouche, Zahia Kabouche, et al.. A new δ-tocotrienolic acid derivative and other constituents from the cones of Cedrus atlantica and their in vitro antimicrobial activity. Phytochemistry Letters, 2017, 20, pp.252-258. ⟨10.1016/j.phytol.2017.05.009⟩. ⟨hal-01996289⟩
55 View
46 Download

Altmetric

Share

Gmail Facebook Twitter LinkedIn More