HAL will be down for maintenance from Friday, June 10 at 4pm through Monday, June 13 at 9am. More information
Skip to Main content Skip to Navigation
Journal articles

A new δ-tocotrienolic acid derivative and other constituents from the cones of Cedrus atlantica and their in vitro antimicrobial activity

Abstract : The phytochemical and antimicrobial properties of the cones of Cedrus atlantica (Endl) Manetti ex Carrière were investigated. Two new compounds (1,2) and nineteen known compounds (3–21) were isolated. Their structures were established by mass spectrometry (HRESIMS), 1D, 2D NMR and by comparison with literature data. Antimicrobial activity of hydromethanolic extract against a panel of 22 bacteria and yeasts showed an interesting antimicrobial activity. All compound purified from this extract were tested against S. aureus by bioautography. MIC values of the most active compounds were determined using a serial dilution technique. The results showed strong antibacterial activity of the abietane diterpenes 10, 11, 14, 15, 16 and 17. Dehydroabietic acid (17) was the most potent against Enterococcus faecalis (MIC = 15.1 = μg/mL), a multi-resistant commensal bacterium which can cause the fatal infections in humans.
Document type :
Journal articles
Complete list of metadata

https://hal.univ-reims.fr/hal-01996289
Contributor : Laurence Voutquenne Connect in order to contact the contributor
Submitted on : Thursday, October 28, 2021 - 2:36:18 PM
Last modification on : Wednesday, February 23, 2022 - 9:14:03 AM
Long-term archiving on: : Saturday, January 29, 2022 - 7:30:59 PM

File

Phytochemestry Letters publi C...
Files produced by the author(s)

Identifiers

Collections

Citation

Maya Belhadj Mostefa, Amin Abedini, Sophie Gangloff, Ahmed Kabouche, Zahia Kabouche, et al.. A new δ-tocotrienolic acid derivative and other constituents from the cones of Cedrus atlantica and their in vitro antimicrobial activity. Phytochemistry Letters, Elsevier, 2017, 20, pp.252-258. ⟨10.1016/j.phytol.2017.05.009⟩. ⟨hal-01996289⟩

Share

Metrics

Record views

55

Files downloads

23