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Triterpene saponins of Genista ulicina Spach

Abstract : From the n-BuOH extract of the aerial parts of Genista ulicina, six triterpene saponins, 3-O-β-D-glucopyranosyl-olean-12-ene-3β,27,28,30-tetraol, 3-O-β-D-glucopyranosyl-olean-12-ene-3β,27,28,29-tetraol, 3,29-di-O-β-D-glucopyranosyl-olean-12-ene-3β,27,28,29-tetraol, 3-O-β-D-glucopyranosyl-olean-12-ene-3β,28,29-triol-27-oic acid, 3-O-β-D-glucopyranosyl-olean-12-ene-3β,27,28-triol-29-oic acid, and 3-O-β-D-glucopyranosyl-14-H-27-nor-olean-12-ene-3β,28,29-triol, were isolated together with eight known triterpene saponins and six flavonoids. Their structures were established mainly by means of spectroscopic methods (1D and 2D-NMR as well as HR-ESI-MS). The n-BuOH extract, investigated for its antitumor growth inhibition of human colon cancer HT-29 cells, presented no significant activity (IC50>100 μg).
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https://hal.univ-reims.fr/hal-01996734
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Naima Boutaghane, Laurence Voutquenne-Nazabadioko, Dominique Harakat, Alain Simon, Zahia Kabouche. Triterpene saponins of Genista ulicina Spach. Phytochemistry, Elsevier, 2013, 93, pp.176-181. ⟨10.1016/j.phytochem.2013.03.020⟩. ⟨hal-01996734⟩

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