The Interleukin-17 Family of Cytokines in Breast Cancer

Joseph Antoine Salvator Fabre 1, 2 Jérôme Giustinniani 3 Christian Garbar 1, 2 Yacine Merrouche 2, 1 Frank Antonicelli 1 Armand Bensussan 4, 2
1 IRMAIC - Immuno-Régulation dans les Maladies Auto-Immunes Inflammatoires et le Cancer - EA 7509
2 Institut Jean Godinot
3 IMRB - Institut Mondor de Recherche Biomédicale
4 Inserm UMR-S 976
Abstract : Breast cancer (BC) is the most common cancer in women worldwide and remains a major cause of mortality with an expected 137,000 death this year in Europe. Standard management of metastatic BC comprises hormonotherapy, chemotherapy, and targeted therapies. Cyclin dependent kinase (CDK) and mammalian target of rapamycin (mTOR) inhibitors have recently proved their efficiency in hormonal receptor expressing BC. Checkpoint proteins inhibition is being evaluated in phase 3 studies. Since inflammation is constantly present in cancers, research teams have focused their attention on the interleukin-17 (IL-17) family of proinflammatory cytokines. Preclinical experiments have reported both pro and antitumor effects depending on the conditions. In the present article, we review the accumulating evidences about the roles of IL-17 in BC and discuss whether this family of cytokines could be a new target in anticancer treatments.
Keywords : immunotherapy new target breast cancer antitumor effects protumor effects interleukin-17
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Joseph Antoine Salvator Fabre, Jérôme Giustinniani, Christian Garbar, Yacine Merrouche, Frank Antonicelli, et al.. The Interleukin-17 Family of Cytokines in Breast Cancer. International Journal of Molecular Sciences, MDPI, 2018, 19 (12), pp.3880. ⟨10.3390/ijms19123880⟩. ⟨hal-02278302⟩

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