Isolation and structure elucidation of cyclopeptide alkaloids from the leaves of Heisteria parvifolia - Archive ouverte HAL Access content directly
Journal Articles Phytochemistry Year : 2019

Isolation and structure elucidation of cyclopeptide alkaloids from the leaves of Heisteria parvifolia

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Abstract

Heisteria parvifolia Sm. is prescribed in traditional medecine against numerous diseases in Côte d'Ivoire. Due to the shortcoming in scientifical knowledge of use of this species, our investigations revealed five undescribed cyclopeptide alkaloids added to one known derivative namely anorldianine. These compounds were elucidated by 1D and 2D-NMR experiments and comparison with literature data, and confirmed by HR-ESI-MS. Cytotoxic activity evaluation of these compounds against the chronic myeloid leukemia (K565) cell line exhibited an antiproliferative activity with cell growth inhibition from 13% to 46%.
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Dates and versions

hal-02310316 , version 1 (22-09-2021)
hal-02310316 , version 2 (24-09-2021)

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Michel Boni Bitchi, Abdulmagid Alabdul-Magid, Faustin Aka Kabran, Philomène Akoua Yao-Kouassi, Dominique Harakat, et al.. Isolation and structure elucidation of cyclopeptide alkaloids from the leaves of Heisteria parvifolia. Phytochemistry, 2019, 167, pp.112081. ⟨10.1016/j.phytochem.2019.112081⟩. ⟨hal-02310316v2⟩
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