Isolation and structure elucidation of cyclopeptide alkaloids from the leaves of Heisteria parvifolia

Heisteria parvifolia Sm. is prescribed in traditional medecine against numerous diseases in Côte d'Ivoire. Due to the shortcoming in scientifical knowledge of use of this species, our investigations revealed five undescribed cyclopeptide alkaloids added to one known derivative namely anorldianine. These compounds were elucidated by 1D and 2D-NMR experiments and comparison with literature data, and confirmed by HR-ESI-MS. Cytotoxic activity evaluation of these compounds against the chronic myeloid leukemia (K565) cell line exhibited an antiproliferative activity with cell growth inhibition from 13% to 46%.

Keywords

Olacaceae Cyclopeptide alkaloids Chronic myeloid leukemia (K565) cell line Cytotoxic activity Heisteria parvifolia

Domains

Medicinal Chemistry Analytical chemistry Botanics

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manuscrit Heisteria parvifolia R3_HAL (1).pdf (494.93 Ko)

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https://hal.univ-reims.fr/hal-02310316

Submitted on : Friday, September 24, 2021-10:46:41 AM

Last modification on : Wednesday, July 31, 2024-10:08:03 AM

Dates and versions

hal-02310316 , version 1 (22-09-2021)

hal-02310316 , version 2 (24-09-2021)

Identifiers

HAL Id : hal-02310316 , version 2
DOI : 10.1016/j.phytochem.2019.112081

Cite

Michel Boni Bitchi, Abdulmagid Alabdul-Magid, Faustin Aka Kabran, Philomène Akoua Yao-Kouassi, Dominique Harakat, et al.. Isolation and structure elucidation of cyclopeptide alkaloids from the leaves of Heisteria parvifolia. Phytochemistry, 2019, 167, pp.112081. ⟨10.1016/j.phytochem.2019.112081⟩. ⟨hal-02310316v2⟩

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