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Journal Articles Diagnostic Microbiology and Infectious Disease Year : 2021

Temocillin susceptibility among Enterobacterales strains recovered from blood culture in France

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Eric Farfour
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Christophe Isnard
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Audrey Mérens
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Abstract

Temocillin is used for several years in some European countries but, only since 2015 in France. We assessed the susceptibility of Enterobacterales strains isolated from blood culture 1 year before (2014) and 2 years after (2017) its use in France. 1,387 strains were included by 17 clinical laboratories located throughout France: 363 in 2014 and 1,024 in 2017. The rate of resistance to temocillin was 4.6% and 26.7% in 3rd generation cephalosporin (3GC) susceptible and resistant strains respectively. Cephalosporinase-overproducer (COPE) strains were significantly more resistant to temocillin (37.7%) than ESBL-producer (ESBL-PE) (23.5%) (P < 0.01). The rate of temocillin resistance was correlated to the number of inactive beta-lactams. The rate of resistance to temocillin trend to increase from 13.9% in 2014 to 23.9% in 2017 (P < 0.01). Temocillin remains highly active against Enterobacterales but the trend in resistance should be assessed over time.
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hal-03216705 , version 1 (27-05-2021)

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Eric Farfour, Anne-Gaëlle Si Larbi, Vincent Cattoir, Stéphane Corvec, Thomas Guillard, et al.. Temocillin susceptibility among Enterobacterales strains recovered from blood culture in France. Diagnostic Microbiology and Infectious Disease, 2021, 100 (3), pp.115368. ⟨10.1016/j.diagmicrobio.2021.115368⟩. ⟨hal-03216705⟩
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