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Journal articles
Temocillin susceptibility among Enterobacterales strains recovered from blood culture in France
Eric Farfour
1, *
Anne-Gaëlle Si Larbi
1
Vincent Cattoir
2, 3
Stéphane Corvec
4
Thomas Guillard
5, 6
Antoine Grillon
7
Christophe Isnard
8
Audrey Mérens
Nicolas Degand
9
Typhaine Billard-Pomares
10
Damien Fournier
11
Emmanuelle Bille
12
Cécile Le Brun
13
Chloé Plouzeau
14
Emilie Flevin
15
Nicolas Yin
16, 17
Paul-Louis Woerther
18
Julie Lourtet
19
Philippe Lesprit
1
Alban Le Monnier
19
*
Corresponding author
8
CHU Caen
Eric Farfour 1
Correspondent author
Anne-Gaëlle Si Larbi 1
Author
Vincent Cattoir 2, 3
Author
Stéphane Corvec 4
Author
Thomas Guillard 5, 6
Author
Antoine Grillon 7
Author
Christophe Isnard 8
Author
Audrey Mérens
Author
Nicolas Degand 9
Author
Typhaine Billard-Pomares 10
Author
Damien Fournier 11
Author
Emmanuelle Bille 12
Author
Paul-Louis Woerther 18
Author
Julie Lourtet 19
Author
Philippe Lesprit 1
Author
Alban Le Monnier 19
Author
1
Hôpital Foch [Suresnes] (40 Rue Worth 92150 Suresnes - France)
2
CHU Pontchaillou [Rennes] (2 Rue Henri le Guilloux, 35000 Rennes - France)
3
BRM - ARN régulateurs bactériens et médecine (Faculté de Pharmacie - Campus Santé Villejean - 2, avenue Prof. Léon Bernard - Bâtiment 5 - 2e étage - CS 34317 - 35043 Rennes cedex - France)
- INSERM - Institut National de la Santé et de la Recherche Médicale : U1230 (101, rue de Tolbiac, 75013 Paris - France)
- Biosit : Biologie - Santé - Innovation Technologique - Structure Fédérative de Recherche en Biologie et Santé de Rennes (Université Rennes 1 - Campus Santé Villejean - 2, avenue Professeur Léon Bernard 35043 Rennes cedex - France)
- UR1 - Université de Rennes 1 (2 rue du Thabor - CS 46510 - 35065 Rennes cedex - France)
- UNIV-RENNES - Université de Rennes (France)
4
CHU Nantes - Centre hospitalier universitaire de Nantes (1 Place Alexis-Ricordeau, 44000 Nantes - France)
5
P3CELL - Pathologies Pulmonaires et Plasticité Cellulaire - UMR-S 1250 (Inserm UMR-S 1250
CHU Maison-Blanche
45, rue Cognacq-Jay
51092 REIMS Cedex - France)
- URCA - Université de Reims Champagne-Ardenne : UMR-S 1250 (2 avenue Robert Schuman, 51100 Reims. - France)
- INSERM - Institut National de la Santé et de la Recherche Médicale : UMR-S 1250 (101, rue de Tolbiac, 75013 Paris - France)
6
CHU Reims - Centre Hospitalier Universitaire de Reims (45, rue Cognacq-Jay 51100 Reims - France)
8
CHU Caen (Avenue de la Côte de Nacre 14000 Caen - France)
- NU - Normandie Université (Esplanade de la Paix - CS 14032 - 14032 Caen Cedex 5 - France)
- TCBN - Tumorothèque de Caen Basse-Normandie (3 avenue du Général Harris 14076 Caen cedex 5 - France)
9
CHU Nice - Centre Hospitalier Universitaire de Nice (30, Voie Romaine
CS 51069 - 06001 Nice Cedex 1 - France)
10
Hôpital Avicenne [AP-HP] (125, rue de Stalingrad 93000 Bobigny - France)
12
INEM - UM 111 (UMR 8253 / U1151) - Institut Necker Enfants-Malades (Bâtiment Leriche
14 rue Maria Helena Vieira Da Silva
75014 Paris - France)
- INSERM - Institut National de la Santé et de la Recherche Médicale : U1151 (101, rue de Tolbiac, 75013 Paris - France)
- CNRS - Centre National de la Recherche Scientifique : UMR 8253 (France)
- UP - Université de Paris : UM 111 (85 boulevard Saint-Germain 75006 Paris - France)
13
Hôpital Bretonneau (2 boulevard Tonnellé, 37044 Tours - France)
14
CHU Poitiers - Centre hospitalier universitaire de Poitiers (2 Rue de la Milétrie, 86021 Poitiers - France)
15
Centre hospitalier de Dieppe (Centre hospitalier de Dieppe, Avenue Pasteur, 76202 Dieppe cedex - France)
16
IGR - Institut Gustave Roussy (114, rue Édouard-Vaillant 94805 Villejuif Cedex -France - France)
17
Génétique (Biologie pathologie) (Gustave Roussy. 114, rue Édouard-Vaillant 94805 Villejuif Cedex -France - France)
- Département de biologie et pathologie médicales [Gustave Roussy] (Gustave Roussy. 114, rue Édouard-Vaillant 94805 Villejuif Cedex -France - France)
- IGR - Institut Gustave Roussy (114, rue Édouard-Vaillant 94805 Villejuif Cedex -France - France)
18
CHU Henri Mondor (Créteil - France)
19
Groupe hospitalier Paris Saint-Joseph - Hôpital (185 Rue Raymond Losserand, 75014 Paris. - France)
Abstract : Temocillin is used for several years in some European countries but, only since 2015 in France. We assessed the susceptibility of Enterobacterales strains isolated from blood culture 1 year before (2014) and 2 years after (2017) its use in France. 1,387 strains were included by 17 clinical laboratories located throughout France: 363 in 2014 and 1,024 in 2017. The rate of resistance to temocillin was 4.6% and 26.7% in 3rd generation cephalosporin (3GC) susceptible and resistant strains respectively. Cephalosporinase-overproducer (COPE) strains were significantly more resistant to temocillin (37.7%) than ESBL-producer (ESBL-PE) (23.5%) (P < 0.01). The rate of temocillin resistance was correlated to the number of inactive beta-lactams. The rate of resistance to temocillin trend to increase from 13.9% in 2014 to 23.9% in 2017 (P < 0.01). Temocillin remains highly active against Enterobacterales but the trend in resistance should be assessed over time.
Document type :
Journal articles
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https://hal.univ-reims.fr/hal-03216705
Contributor : Valerian Dormoy <>
Submitted on : Thursday, May 27, 2021 - 11:11:53 AM
Last modification on : Wednesday, September 22, 2021 - 10:01:52 AM
Long-term archiving on: : Saturday, August 28, 2021 - 6:40:39 PM
Contributor : Valerian Dormoy <>
Submitted on : Thursday, May 27, 2021 - 11:11:53 AM
Last modification on : Wednesday, September 22, 2021 - 10:01:52 AM
Long-term archiving on: : Saturday, August 28, 2021 - 6:40:39 PM
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Farfour et al. - 2021 - Temoci...
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Identifiers
- HAL Id : hal-03216705, version 1
- DOI : 10.1016/j.diagmicrobio.2021.115368
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UNIV-RENNES1 | P3CELL | UNIV-RENNES | UNIV-PARIS | UP-SANTE | UR1-UFR-SVE | BIOSIT | U835 | CNRS | URCA | FNCLCC | COMUE-NORMANDIE | IGR
Citation
Eric Farfour, Anne-Gaëlle Si Larbi, Vincent Cattoir, Stéphane Corvec, Thomas Guillard, et al.. Temocillin susceptibility among Enterobacterales strains recovered from blood culture in France. Diagnostic Microbiology and Infectious Disease, Elsevier, 2021, 100 (3), pp.115368. ⟨10.1016/j.diagmicrobio.2021.115368⟩. ⟨hal-03216705⟩
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