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Journal Articles Cancers Year : 2021

Hypoxia in Lung Cancer Management: A Translational Approach

Julien Ancel
Jeanne-Marie Perotin
  • Function : Author
Maxime Dewolf
  • Function : Author
Claire Launois
Pauline Mulette
  • Function : Author
Véronique Dalstein
  • Function : Author
Christine Gilles
  • Function : Author
Gaëtan Deslée
  • Function : Author


Lung cancer represents the first cause of death by cancer worldwide and remains a challenging public health issue. Hypoxia, as a relevant biomarker, has raised high expectations for clinical practice. Here, we review clinical and pathological features related to hypoxic lung tumours. Secondly, we expound on the main current techniques to evaluate hypoxic status in NSCLC focusing on positive emission tomography. We present existing alternative experimental approaches such as the examination of circulating markers and highlight the interest in non-invasive markers. Finally, we evaluate the relevance of investigating hypoxia in lung cancer management as a companion biomarker at various lung cancer stages. Hypoxia could support the identification of patients with higher risks of NSCLC. Moreover, the presence of hypoxia in treated tumours could help clinicians predict a worse prognosis for patients with resected NSCLC and may help identify patients who would benefit potentially from adjuvant therapies. Globally, the large quantity of translational data incites experimental and clinical studies to implement the characterisation of hypoxia in clinical NSCLC management.
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Dates and versions

hal-03325614 , version 1 (25-08-2021)



Julien Ancel, Jeanne-Marie Perotin, Maxime Dewolf, Claire Launois, Pauline Mulette, et al.. Hypoxia in Lung Cancer Management: A Translational Approach. Cancers, 2021, 13 (14), pp.3421. ⟨10.3390/cancers13143421⟩. ⟨hal-03325614⟩


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