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Antioxidant activity-guided isolation of constituents from Euphorbia gaditana Coss. and their antioxidant and tyrosinase inhibitory activities

Abstract : Two previously unreported compounds, 4-O-(2′′-O-galloyl-β-d-glucopyranosyl)-3,5-dihydroxyacetophenone (1) and 5-isopropyl-2-oxo-3,6-dihydropyran-4-carboxylic acid (2), along with twenty-nine known compounds (3−31) were isolated from the aerial parts of Euphorbia gaditana Coss. Their structures were elucidated based on extensive spectroscopic analysis 1D and 2D-NMR, mass spectrometry HR-ESI-MS, optical rotation [α]D, acid hydrolysis and the comparison of NMR data with those described in literature. The antioxidant activity-guided study was conducted using DPPH and CUPRAC methods started from the extracts to bioactive isolated molecules. Most of the isolates (1-31) showed a good to excellent antioxidant activity compared to the standards BHT and ascorbic acid. Furthermore, 1 and 2 exhibited a moderate tyrosinase inhibitory activity (IC50 89.78 ± 0.93 and 52.39 ± 0.69 μg/mL, respectively) compared to the standard kojic acid (IC50 25.23 ± 0.78 μg/mL).
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https://hal.univ-reims.fr/hal-03339949
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Submitted on : Wednesday, September 22, 2021 - 11:41:51 AM
Last modification on : Friday, August 5, 2022 - 11:22:46 AM
Long-term archiving on: : Thursday, December 23, 2021 - 6:32:36 PM

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Mohamed Ibrahim Badaoui, Abdulmagid Alabdul Magid, Laurence Voutquenne-Nazabadioko, Mohammed Benkhaled, Dominique Harakat, et al.. Antioxidant activity-guided isolation of constituents from Euphorbia gaditana Coss. and their antioxidant and tyrosinase inhibitory activities. Phytochemistry Letters, Elsevier, 2020, 39, pp.99-104. ⟨10.1016/j.phytol.2020.07.012⟩. ⟨hal-03339949⟩

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