Comparison of Continuous Glucose Monitoring in Cystic Fibrosis Patients With or Without Pancreatic Exocrine Insufficiency - Archive ouverte HAL Access content directly
Journal Articles Hormone and Metabolic Research Year : 2022

Comparison of Continuous Glucose Monitoring in Cystic Fibrosis Patients With or Without Pancreatic Exocrine Insufficiency

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1
Luc Rakotoarisoa
Laurence Weiss
  • Function : Author
François Lefebvre
  • Function : Author
Michele Porzio
  • Function : Author
Bruno Ravoninjatovo
  • Function : Author
Isabelle Danner Boucher
  • Function : Author
Séverine Dubois
  • Function : Author
Françoise Troussier
  • Function : Author
Rault Gilles
  • Function : Author
Anne Prevotat
  • Function : Author
Laurence Kessler
  • Function : Author

Abstract

Abstract This study aimed to compare continuous glucose monitoring (CGM) in cystic fibrosis (CF) according to pancreatic exocrine status. CGM and oral glucose tolerance testing (OGTT) were realized annually over five years in people with CF (pwCF) aged≥10 years without cystic fibrosis-related diabetes (CFRD). CGM parameters in patients with normal glucose tolerance (NGT), impaired glucose tolerance (IGT), and newly diagnosed CFRD were compared according to presence of pancreatic sufficiency (PS) or insufficiency (PI). Overall, 547 OGTTs and 501 CGMs were performed in 147 CF patients, comprising 122 PI and 25 PS. In PS patients, 84% displayed NGT, 12% IGT, and 4% CFRD vs. 58%, 32%, and 10% (p=0.05) in PI. Among participants displaying normal OGTT, time in glucose range (70–140 mg/dl) was significantly increased, 97% (93, 99) vs. 92% (85, 96), p<0.001, and time above glucose range > 140 mg/dl significantly decreased, 1% (0, 2) % vs. 6% (2, 13), in patients with PS compared to those with PI. No significant differences were highlighted in patients with IGT. CGM revealed significant different glucose tolerance abnormalities in PI versus PS, which were undetected by standard 2-hour OGTT glucose.
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Dates and versions

hal-03671219 , version 1 (18-05-2022)

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Luc Rakotoarisoa, Laurence Weiss, François Lefebvre, Michele Porzio, Bruno Ravoninjatovo, et al.. Comparison of Continuous Glucose Monitoring in Cystic Fibrosis Patients With or Without Pancreatic Exocrine Insufficiency. Hormone and Metabolic Research, 2022, ⟨10.1055/a-1794-5496⟩. ⟨hal-03671219⟩

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