Comparison of Continuous Glucose Monitoring in Cystic Fibrosis Patients With or Without Pancreatic Exocrine Insufficiency - Université de Reims Champagne-Ardenne
Article Dans Une Revue Hormone and Metabolic Research Année : 2022

Comparison of Continuous Glucose Monitoring in Cystic Fibrosis Patients With or Without Pancreatic Exocrine Insufficiency

Luc Rakotoarisoa
Laurence Weiss
  • Fonction : Auteur
François Lefebvre
  • Fonction : Auteur
Michele Porzio
  • Fonction : Auteur
Bruno Ravoninjatovo
  • Fonction : Auteur
Isabelle Danner Boucher
  • Fonction : Auteur
Séverine Dubois
  • Fonction : Auteur
Françoise Troussier
  • Fonction : Auteur
Rault Gilles
  • Fonction : Auteur
Anne Prevotat
Laurence Kessler
  • Fonction : Auteur

Résumé

Abstract This study aimed to compare continuous glucose monitoring (CGM) in cystic fibrosis (CF) according to pancreatic exocrine status. CGM and oral glucose tolerance testing (OGTT) were realized annually over five years in people with CF (pwCF) aged≥10 years without cystic fibrosis-related diabetes (CFRD). CGM parameters in patients with normal glucose tolerance (NGT), impaired glucose tolerance (IGT), and newly diagnosed CFRD were compared according to presence of pancreatic sufficiency (PS) or insufficiency (PI). Overall, 547 OGTTs and 501 CGMs were performed in 147 CF patients, comprising 122 PI and 25 PS. In PS patients, 84% displayed NGT, 12% IGT, and 4% CFRD vs. 58%, 32%, and 10% (p=0.05) in PI. Among participants displaying normal OGTT, time in glucose range (70–140 mg/dl) was significantly increased, 97% (93, 99) vs. 92% (85, 96), p<0.001, and time above glucose range > 140 mg/dl significantly decreased, 1% (0, 2) % vs. 6% (2, 13), in patients with PS compared to those with PI. No significant differences were highlighted in patients with IGT. CGM revealed significant different glucose tolerance abnormalities in PI versus PS, which were undetected by standard 2-hour OGTT glucose.
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Dates et versions

hal-03671219 , version 1 (18-05-2022)

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Luc Rakotoarisoa, Laurence Weiss, François Lefebvre, Michele Porzio, Bruno Ravoninjatovo, et al.. Comparison of Continuous Glucose Monitoring in Cystic Fibrosis Patients With or Without Pancreatic Exocrine Insufficiency. Hormone and Metabolic Research, 2022, ⟨10.1055/a-1794-5496⟩. ⟨hal-03671219⟩

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