Methods and criteria for validating the multimodal functions of perinatal derivatives when used in oncological and antimicrobial applications - Université de Reims Champagne-Ardenne Access content directly
Journal Articles Frontiers in Bioengineering and Biotechnology Year : 2023

Methods and criteria for validating the multimodal functions of perinatal derivatives when used in oncological and antimicrobial applications

Antonietta Silini
  • Function : Author
Taja Železnik Ramuta
  • Function : Author
Ana Salomé Pires
  • Function : Author
Asmita Banerjee
  • Function : Author
Florelle Gindraux
  • Function : Author
Justinas Maciulatis
  • Function : Author
Adelheid Weidinger
  • Function : Author
Susanne Wolbank
  • Function : Author
Günther Eissner
  • Function : Author
Bernd Giebel
  • Function : Author
Michela Pozzobon
  • Function : Author
Ornella Parolini
  • Function : Author
Mateja Erdani Kreft
  • Function : Author

Abstract

Perinatal derivatives or PnDs refer to tissues, cells and secretomes from perinatal, or birth-associated tissues. In the past 2 decades PnDs have been highly investigated for their multimodal mechanisms of action that have been exploited in various disease settings, including in different cancers and infections. Indeed, there is growing evidence that PnDs possess anticancer and antimicrobial activities, but an urgent issue that needs to be addressed is the reproducible evaluation of efficacy, both in vitro and in vivo . Herein we present the most commonly used functional assays for the assessment of antitumor and antimicrobial properties of PnDs, and we discuss their advantages and disadvantages in assessing the functionality. This review is part of a quadrinomial series on functional assays for the validation of PnDs spanning biological functions such as immunomodulation, anticancer and antimicrobial, wound healing, and regeneration.
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hal-04040066 , version 1 (21-03-2023)

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Antonietta Silini, Taja Železnik Ramuta, Ana Salomé Pires, Asmita Banerjee, Marie Dubus, et al.. Methods and criteria for validating the multimodal functions of perinatal derivatives when used in oncological and antimicrobial applications. Frontiers in Bioengineering and Biotechnology, 2023, 10, ⟨10.3389/fbioe.2022.958669⟩. ⟨hal-04040066⟩

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