Molecular allergology: a clinical laboratory tool for precision diagnosis, stratification and follow-up of allergic patients - Université de Reims Champagne-Ardenne Access content directly
Journal Articles Clinical Chemistry and Laboratory Medicine Year : 2024

Molecular allergology: a clinical laboratory tool for precision diagnosis, stratification and follow-up of allergic patients

Delphine Giusti
Amir Guemari
Jean-François Fontaine
  • Function : Author
Marcelle Tonye Libyh
Gregory Gatouillat
Thierry Tabary
Bach-Nga Pham
Joana Vitte

Abstract

Abstract Identification of the molecular culprits of allergic reactions leveraged molecular allergology applications in clinical laboratory medicine. Molecular allergology shifted the focus from complex, heterogeneous allergenic extracts, e.g. pollen, food, or insect venom, towards genetically and immunologically defined proteins available for in vitro diagnosis. Molecular allergology is a precision medicine approach for the diagnosis, stratification, therapeutic management, follow-up and prognostic evaluation of patients within a large range of allergic diseases. Exclusively available for in vitro diagnosis, molecular allergology is nonredundant with any of the current clinical tools for allergy investigation. As an example of a major application, discrimination of genuine sensitization from allergen cross-reactivity at the molecular level allows the proper targeting of the culprit allergen and thus dramatically improves patient management. This review aims at introducing clinical laboratory specialists to molecular allergology, from the biochemical and genetic bases, through immunological concepts, to daily use in the diagnosis and management of allergic diseases.
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Dates and versions

hal-04601536 , version 1 (05-06-2024)

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Delphine Giusti, Amir Guemari, Jeanne‐marie Perotin, Jean-François Fontaine, Marcelle Tonye Libyh, et al.. Molecular allergology: a clinical laboratory tool for precision diagnosis, stratification and follow-up of allergic patients. Clinical Chemistry and Laboratory Medicine, 2024, ⟨10.1515/cclm-2024-0305⟩. ⟨hal-04601536⟩

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