Viral myocarditis in combination with genetic cardiomyopathy as a cause of sudden death. An autopsy series - Université de Reims Champagne-Ardenne
Article Dans Une Revue BMC Cardiovascular Disorders Année : 2024

Viral myocarditis in combination with genetic cardiomyopathy as a cause of sudden death. An autopsy series

Résumé

Abstract Sudden cardiac death (SCD) is a major public health issue worldwide. In the young (< 40 years of age), genetic cardiomyopathies and viral myocarditis, sometimes in combination, are the most frequent, but underestimated, causes of SCD. Molecular autopsy is essential for prevention. Several studies have shown an association between genetic cardiomyopathies and viral myocarditis, which is probably underestimated due to insufficient post-mortem investigations. We report on four autopsy cases illustrating the pathogenesis of these combined pathologies. In two cases, a genetic hypertrophic cardiomyopathy was diagnosed in combination with Herpes Virus Type 6 (HHV6) and/or Parvovirus-B19 (PVB19) in the heart. In the third case, autopsy revealed a dilated cardiomyopathy and virological analyses revealed acute myocarditis caused by three viruses: PVB19, HHV6 and Epstein-Barr virus. Genetic analyses revealed a mutation in the gene coding for desmin. The fourth case illustrated a channelopathy and a PVB19/HHV6 coinfection. Our four cases illustrate the highly probable deleterious role of cardiotropic viruses in the occurrence of SCD in subjects with genetic cardiomyopathies. We discuss the pathogenetic link between viral myocarditis and genetic cardiomyopathy. Molecular autopsy is essential in prevention of these SCD, and a close collaboration between cardiologists, pathologists, microbiologists and geneticians is mandatory.

Domaines

Virologie
Fichier principal
Vignette du fichier
BMC_CardiovascularDis.pdf (1.33 Mo) Télécharger le fichier
Origine Fichiers éditeurs autorisés sur une archive ouverte
Licence

Dates et versions

hal-04802789 , version 1 (25-11-2024)

Licence

Identifiants

Citer

Domitille Callon, Pierre Joanne, Laurent Andreoletti, Onnik Agbulut, Philippe Chevalier, et al.. Viral myocarditis in combination with genetic cardiomyopathy as a cause of sudden death. An autopsy series. BMC Cardiovascular Disorders, 2024, 24 (1), pp.282. ⟨10.1186/s12872-024-03913-z⟩. ⟨hal-04802789⟩
0 Consultations
0 Téléchargements

Altmetric

Partager

More