Spastic dystonia is defined as tonic involuntary muscle activation at rest superimposed over spastic paresis [1]. It occurs in different pathological conditions, ranging from dopamine-dependent dystonia [2] to post-stroke deforming spastic hemiparesis [1]. Even though important burden is associated to spastic dystonia, therapeutic options are scarce and mostly limited to intramuscular botulinum toxin injection and surgical partial nerve section. Repetitive transcranial magnetic stimulation (rTMS) has been proposed as an interesting therapeutic option, but with inconsistent results [3]. We suggest that optimized targeting based on functional brain imaging could enhance the results of rTMS in schizencephaly-related dystonia and improve our knowledge about the technical procedure to become more widely applicable in neurodevelopmental disorders.