Relationship between serotypes, disease characteristics and 30-day mortality in adults with invasive pneumococcal disease
Amine Benadji
(1)
,
Kostas Danis
,
Nathalie Brieu
,
Jacques Gaillat
,
Bruno Mourvillier
,
Pierre-Edouard Bollaert
,
Olivier Gaillot
,
Muhamed-Kheir Taha
,
Stephane Bonacorsi
,
Marc Lecuit
,
Bruno Frachet
,
Thomas Debroucker
,
Daniel Levy Bruhl
,
Marie Preau
,
Nadia Anguel
,
Laurent Argaud
,
Sophie Arista
,
Laurence Armand-Lefevre
,
Stéphanie Balavoine
,
Régine Baraduc
,
Guilène Barnaud
,
Guillaume Béraud
,
Georges Bernars
,
Dominique Bertei
,
Emilie Bessede
,
Typhaine Billard Pomares
,
Charlotte Biron
,
Stéphane Bland
,
Julien Boileau
,
Patrice Boubeau
,
Sandra Bourdon
,
Aurore Bousquet
,
Sophie Boyer
,
Alexis Bozorg-Grayeli
,
Cédric Bretonniere
,
François Bricaire
,
Elsa Brocas
,
Michel Brun
,
Jennifer Buret
,
Christophe Burucoa
,
Jean Cabalion
,
Mathieu Cabon
,
Emmanuelle Cambau
,
Guillaume Camuset
,
Christophe Canevet
,
François Caron
,
Anne Carricajo
,
Bernard Castan
,
Eric Caumes
,
Charles Cazanave
,
Amélie Chabrol
,
Thibaut Challan-Belval
,
Vanessa Chanteperdrix-Marillier
,
Chantal Chaplain
,
Caroline Charlier-Woerther
,
Hélène Chaussade
,
Catherine Chirouze
(2, 3)
,
Bernard Clair
,
Julien Colot
,
Jean-Marie Conil
,
Hugues Cordel
,
Philippe Cormier
,
Joël Cousson
,
Pierrick Cronier
,
Eric Cua
,
Anne Dao-Dubremetz
,
Sylvie Dargere
,
Nicolas Degand
,
Sophie Dekeyser
,
Deborah Delaune
,
Eric Denes
,
Pierre-Francois Dequin
,
Diane Descamps
,
Elodie Descloux
,
Jean-Luc Desmaretz
,
Jean-Luc Diehl
,
Jérôme Dimet
,
Aurélien Dinh
,
Xavier Duval
(1, 4)
,
Lelia Escaut
,
Claude Fabe
,
Frédéric Faibis
,
Clara Flateau
,
Nathalie Fonsale
,
Nicolas Fortineau
,
Amandine Gagneux-Brunon
,
Caroline Garandeau
,
Magali Garcia
,
Denis Garot
,
Stéphane Gaudry
,
François Goehringer
,
Alain Gravet
,
Valérie Gregoire-Faucher
,
Marine Grosset
,
Isabelle Gueit
,
Dominique Guelon
,
Thomas Guimard
,
Tahar Hadou
,
Jean-Pierre Helene
,
Sandrine Henard
,
Benoit Henry
,
Anne-Cécile Hochart
,
Bruno Hoen
,
Gabriela Illes
,
Sylvain Jaffuel
,
Irène Jarrin
,
Françoise Jaureguy
,
Cédric Joseph
,
Marie-Emmanuelle Juvin
,
Samer Kayal
,
Solen Kerneis
,
Isabelle Lamaury
,
Etienne Laurens
,
Henri Laurichesse
,
Cécile Le Brun
,
Vincent Le Moing
,
Paul Le Turnier
,
Hervé Lecuyer
,
Sylvie Ledru
,
Céline Legrix
,
Adrien Lemaignen
,
Chantal Lemble
,
Ludovic Lemee
,
Olivier Lesens
,
Claire Lhommet
,
Silvija Males
,
Edith Malpote
,
Guillaume Martin-Blondel
,
Matthieu Marx
,
Raphael Masson
,
Olivier Matray
,
Aurore Mbadi
,
Frédéric Mechai
,
Guillaume Mellon
,
Audrey Merens
,
Marie Caroline Meyohas
,
Adrien Michon
,
Joy Mootien Yoganaden
,
David Morquin
,
Stéphane Mouly
,
Natacha Mrozek
,
Sophie Nguyen
,
Eric Oziol
,
Bernard Page
,
Solène Patrat-Delon
,
Isabelle Patry
,
Sandrine Picot
,
Denys Pierrejean
,
Lionel Piroth
,
Claire Plassart
,
Patrice Plessis
,
Marie-Cécile Ploy
(5)
,
Laurent Portel
,
Patrice Poubeau
,
Marie Poupard
,
Claire Poyart
,
Thierry Prazuck
,
Luc Quaesaet
,
François Raffi
,
Adriatsiferana Ramanantsoa
,
Christophe Rapp
,
Laurent Raskine
,
Josette Raymond
,
Matthieu Revest
(6, 7)
,
Agnès Riche
,
Stéphanie Robaday-Voisin
,
Frédéric Robin
,
Jean-Pierre Romaszko
,
Florence Rousseau
,
Anne-Laure Roux
,
Cécile Royer
,
Matthieu Saada
,
Dominique Salmon
,
Carlo Saroufim
,
Jean Luc Schmit
,
Manuela Sebire
,
Christine Segonds
,
Valérie Sivadon-Tardy
,
Nathalie Soismier
,
Olivia Son
,
Simon Sunder
,
Florence Suy
,
Didier Tande
,
Jacques Tankovic
,
Nadia Valin
,
Nicolas van Grunderbeeck
,
François Vandenesch
,
Emmanuelle Varon
(8)
,
Renaud Verdon
,
Michel Vergnaud
,
Magali Vidal
,
Daniel Vittecoq
,
Fanny Vuotto
,
Isabelle Gorenne
,
Cédric Laouenan
,
Estelle Marcault
,
France Mentre
,
Blandine Pasquet
,
Carine Roy
,
Sarah Tubiana
(1, 4)
,
Philippe Arsac
,
Martha Benoit
,
Louis Bernard
,
François Bissuel
,
Laurent Bret
,
Natalie Brieu
,
Jennifer Burret
,
Claudia Carvalhoschneider
,
Hélène Champagne
,
Joséphine Chapalain
,
Hubert Chardon
,
Pascal Chavanet
,
Judith Ducruet
,
Olivier Epaulard
,
Marc Fabre
,
Dominique Fasquelle
,
Emmanuel Forestier
,
Jean-Marc Galempoix
,
Guillaume Gautier
,
Claire Goulard de Curraize
,
Alain Gracet
,
Camélia Gubavu
,
Jérôme Guinard
,
Tarik Habet
,
Aurélie Haudour
,
Caroline Henry
,
Cécile Hombrouckalet
,
Céline Janssen
,
Jean-Paul Kisteman
,
Philippe Lanotte
,
Marie-Frédérique Lartigue
,
Claire Launois
,
Cécile Lebrun
,
Laurence Legout
,
Marion Levast
,
Yannick Madoux
,
Laurence Maulin
,
Stéphanie Mestrallet
,
Abdo Mohareb
,
Joy Mootien
,
Yohan Nguyen
,
Franck Noel
,
Maja Ogielska
,
Agathe Ogier Desserrey
,
Anne Paleau
,
Simona Pavel
,
André Pechinot
,
Isabelle Pelloux
,
Camille Petillon
,
Hélène Petitprez
,
Bianca Podac
,
Jerome Poirot
,
Bénédicte Ponceau
,
Nathalie Prieur
,
Christine Recule
,
Orlando Saraceni
,
Jacques Sartre
,
Farid Sifaoui
,
Catherine Simonin
,
Christophe Strady
,
Charlotte Tellini
,
Anthony Texier
,
Maxime Thouvenin
,
Anne Tixier
,
Pauline Tremeaux
,
Pascale Verger
,
Véronique Vernet-Garnier
(9)
,
Jean-Pierre Verquin
,
Virginie Vitrat
,
Isabelle Vray
,
Oana Zamfir
,
Laure Zucchini
1
CIC 1425 -
Centre d'investigation Clinique [CHU Bichat] - Épidémiologie clinique
2 LCE - Laboratoire Chrono-environnement (UMR 6249)
3 CHRU Besançon - Centre Hospitalier Régional Universitaire de Besançon
4 IAME (UMR_S_1137 / U1137) - Infection, Anti-microbiens, Modélisation, Evolution
5 RESINFIT - Anti-infectieux : supports moléculaires des résistances et innovations thérapeutiques
6 BRM - ARN régulateurs bactériens et médecine
7 Centre Hospitalier Universitaire de Rennes [CHU Rennes] = Rennes University Hospital [Pontchaillou]
8 CHI Créteil
9 P3CELL - Pathologies Pulmonaires et Plasticité Cellulaire - UMR-S 1250
2 LCE - Laboratoire Chrono-environnement (UMR 6249)
3 CHRU Besançon - Centre Hospitalier Régional Universitaire de Besançon
4 IAME (UMR_S_1137 / U1137) - Infection, Anti-microbiens, Modélisation, Evolution
5 RESINFIT - Anti-infectieux : supports moléculaires des résistances et innovations thérapeutiques
6 BRM - ARN régulateurs bactériens et médecine
7 Centre Hospitalier Universitaire de Rennes [CHU Rennes] = Rennes University Hospital [Pontchaillou]
8 CHI Créteil
9 P3CELL - Pathologies Pulmonaires et Plasticité Cellulaire - UMR-S 1250
Kostas Danis
- Function : Author
Nathalie Brieu
- Function : Author
Jacques Gaillat
- Function : Author
Bruno Mourvillier
- Function : Author
Pierre-Edouard Bollaert
- Function : Author
- PersonId : 919251
- IdRef : 059868732
Olivier Gaillot
- Function : Author
Muhamed-Kheir Taha
- Function : Author
Stephane Bonacorsi
- Function : Author
- PersonId : 1044082
- ORCID : 0000-0001-6447-6874
Marc Lecuit
- Function : Author
- PersonId : 756321
- ORCID : 0000-0002-4491-1063
- IdRef : 060744529
Bruno Frachet
- Function : Author
Thomas Debroucker
- Function : Author
Daniel Levy Bruhl
- Function : Author
Marie Preau
- Function : Author
- PersonId : 171105
- IdHAL : preau-marie
- ORCID : 0000-0002-6239-1671
- IdRef : 084340525
Nadia Anguel
- Function : Author
Laurent Argaud
- Function : Author
Sophie Arista
- Function : Author
Laurence Armand-Lefevre
- Function : Author
- PersonId : 948287
- IdRef : 137056591
Stéphanie Balavoine
- Function : Author
Régine Baraduc
- Function : Author
Guilène Barnaud
- Function : Author
Guillaume Béraud
- Function : Author
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- IdHAL : guillaume-beraud
- ORCID : 0000-0002-4705-0916
- IdRef : 113639562
Georges Bernars
- Function : Author
Dominique Bertei
- Function : Author
Emilie Bessede
- Function : Author
Typhaine Billard Pomares
- Function : Author
Charlotte Biron
- Function : Author
Stéphane Bland
- Function : Author
Julien Boileau
- Function : Author
Patrice Boubeau
- Function : Author
Sandra Bourdon
- Function : Author
Aurore Bousquet
- Function : Author
Sophie Boyer
- Function : Author
Alexis Bozorg-Grayeli
- Function : Author
- PersonId : 996437
- ORCID : 0000-0002-4353-9431
- IdRef : 074099752
Cédric Bretonniere
- Function : Author
François Bricaire
- Function : Author
Elsa Brocas
- Function : Author
Michel Brun
- Function : Author
Jennifer Buret
- Function : Author
Christophe Burucoa
- Function : Author
- PersonId : 919896
Jean Cabalion
- Function : Author
Mathieu Cabon
- Function : Author
Emmanuelle Cambau
- Function : Author
Guillaume Camuset
- Function : Author
Christophe Canevet
- Function : Author
François Caron
- Function : Author
Anne Carricajo
- Function : Author
Bernard Castan
- Function : Author
Eric Caumes
- Function : Author
Charles Cazanave
- Function : Author
Amélie Chabrol
- Function : Author
Thibaut Challan-Belval
- Function : Author
Vanessa Chanteperdrix-Marillier
- Function : Author
Chantal Chaplain
- Function : Author
Caroline Charlier-Woerther
- Function : Author
Hélène Chaussade
- Function : Author
Catherine Chirouze
- Function : Author
- PersonId : 760630
- ORCID : 0000-0002-6150-2376
- IdRef : 058486186
Bernard Clair
- Function : Author
Julien Colot
- Function : Author
Jean-Marie Conil
- Function : Author
Hugues Cordel
- Function : Author
Philippe Cormier
- Function : Author
Joël Cousson
- Function : Author
Pierrick Cronier
- Function : Author
Eric Cua
- Function : Author
Anne Dao-Dubremetz
- Function : Author
Sylvie Dargere
- Function : Author
Nicolas Degand
- Function : Author
Sophie Dekeyser
- Function : Author
Deborah Delaune
- Function : Author
- PersonId : 808702
- ORCID : 0000-0003-4970-9566
Eric Denes
- Function : Author
Pierre-Francois Dequin
- Function : Author
Diane Descamps
- Function : Author
Elodie Descloux
- Function : Author
Jean-Luc Desmaretz
- Function : Author
Jean-Luc Diehl
- Function : Author
Jérôme Dimet
- Function : Author
Aurélien Dinh
- Function : Author
Xavier Duval
- Function : Correspondent author
Lelia Escaut
- Function : Author
Claude Fabe
- Function : Author
Frédéric Faibis
- Function : Author
Clara Flateau
- Function : Author
Nathalie Fonsale
- Function : Author
Nicolas Fortineau
- Function : Author
Amandine Gagneux-Brunon
- Function : Author
- PersonId : 1157668
- ORCID : 0000-0002-0892-2187
Caroline Garandeau
- Function : Author
Magali Garcia
- Function : Author
- PersonId : 1120180
- ORCID : 0000-0001-6611-8683
- IdRef : 155009354
Denis Garot
- Function : Author
Stéphane Gaudry
- Function : Author
François Goehringer
- Function : Author
Alain Gravet
- Function : Author
Valérie Gregoire-Faucher
- Function : Author
Marine Grosset
- Function : Author
Isabelle Gueit
- Function : Author
Dominique Guelon
- Function : Author
Thomas Guimard
- Function : Author
Tahar Hadou
- Function : Author
Jean-Pierre Helene
- Function : Author
Sandrine Henard
- Function : Author
Benoit Henry
- Function : Author
Anne-Cécile Hochart
- Function : Author
Bruno Hoen
- Function : Author
- PersonId : 11357
- IdHAL : bruno-hoen
- ORCID : 0000-0003-3070-3017
- IdRef : 058486194
Gabriela Illes
- Function : Author
Sylvain Jaffuel
- Function : Author
Irène Jarrin
- Function : Author
Françoise Jaureguy
- Function : Author
Cédric Joseph
- Function : Author
- PersonId : 1145782
- ORCID : 0000-0003-1878-9858
- IdRef : 160767741
Marie-Emmanuelle Juvin
- Function : Author
Samer Kayal
- Function : Author
Solen Kerneis
- Function : Author
Isabelle Lamaury
- Function : Author
Etienne Laurens
- Function : Author
Henri Laurichesse
- Function : Author
Cécile Le Brun
- Function : Author
- PersonId : 968811
- ORCID : 0000-0002-9846-0210
- IdRef : 079397913
Vincent Le Moing
- Function : Author
Paul Le Turnier
- Function : Author
Hervé Lecuyer
- Function : Author
Sylvie Ledru
- Function : Author
Céline Legrix
- Function : Author
Adrien Lemaignen
- Function : Author
Chantal Lemble
- Function : Author
Ludovic Lemee
- Function : Author
Olivier Lesens
- Function : Author
Claire Lhommet
- Function : Author
Silvija Males
- Function : Author
Edith Malpote
- Function : Author
Guillaume Martin-Blondel
- Function : Author
- PersonId : 1094314
- ORCID : 0000-0002-8363-7028
- IdRef : 138922896
Matthieu Marx
- Function : Author
Raphael Masson
- Function : Author
Olivier Matray
- Function : Author
Aurore Mbadi
- Function : Author
Frédéric Mechai
- Function : Author
Guillaume Mellon
- Function : Author
Audrey Merens
- Function : Author
Marie Caroline Meyohas
- Function : Author
Adrien Michon
- Function : Author
- PersonId : 750453
- IdHAL : adrien-michon
- ORCID : 0000-0002-8870-3696
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Joy Mootien Yoganaden
- Function : Author
David Morquin
- Function : Author
Stéphane Mouly
- Function : Author
Natacha Mrozek
- Function : Author
Sophie Nguyen
- Function : Author
Eric Oziol
- Function : Author
Bernard Page
- Function : Author
Solène Patrat-Delon
- Function : Author
Isabelle Patry
- Function : Author
Sandrine Picot
- Function : Author
Denys Pierrejean
- Function : Author
Lionel Piroth
- Function : Author
Claire Plassart
- Function : Author
Patrice Plessis
- Function : Author
Laurent Portel
- Function : Author
Patrice Poubeau
- Function : Author
Marie Poupard
- Function : Author
Claire Poyart
- Function : Author
Thierry Prazuck
- Function : Author
Luc Quaesaet
- Function : Author
François Raffi
- Function : Author
Adriatsiferana Ramanantsoa
- Function : Author
Christophe Rapp
- Function : Author
Laurent Raskine
- Function : Author
Josette Raymond
- Function : Author
Matthieu Revest
- Function : Author
- PersonId : 765595
- ORCID : 0000-0001-8896-3060
- IdRef : 120446855
Agnès Riche
- Function : Author
Stéphanie Robaday-Voisin
- Function : Author
Frédéric Robin
- Function : Author
Jean-Pierre Romaszko
- Function : Author
Florence Rousseau
- Function : Author
Anne-Laure Roux
- Function : Author
Cécile Royer
- Function : Author
Matthieu Saada
- Function : Author
Dominique Salmon
- Function : Author
- PersonId : 807547
- ORCID : 0000-0002-6817-8951
Carlo Saroufim
- Function : Author
Jean Luc Schmit
- Function : Author
- PersonId : 1146074
- IdRef : 074662236
Manuela Sebire
- Function : Author
Christine Segonds
- Function : Author
Valérie Sivadon-Tardy
- Function : Author
Nathalie Soismier
- Function : Author
Olivia Son
- Function : Author
Simon Sunder
- Function : Author
Florence Suy
- Function : Author
Didier Tande
- Function : Author
Jacques Tankovic
- Function : Author
Nadia Valin
- Function : Author
Nicolas van Grunderbeeck
- Function : Author
François Vandenesch
- Function : Author
- PersonId : 866586
- ORCID : 0000-0001-9412-7106
- IdRef : 081109040
Renaud Verdon
- Function : Author
Michel Vergnaud
- Function : Author
Magali Vidal
- Function : Author
Daniel Vittecoq
- Function : Author
Fanny Vuotto
- Function : Author
Isabelle Gorenne
- Function : Author
Cédric Laouenan
- Function : Author
Estelle Marcault
- Function : Author
France Mentre
- Function : Author
Blandine Pasquet
- Function : Author
Carine Roy
- Function : Author
Sarah Tubiana
- Function : Author
- PersonId : 777864
- ORCID : 0000-0002-6526-6403
- IdRef : 175809259
Philippe Arsac
- Function : Author
Martha Benoit
- Function : Author
Louis Bernard
- Function : Author
François Bissuel
- Function : Author
Laurent Bret
- Function : Author
Natalie Brieu
- Function : Author
Jennifer Burret
- Function : Author
Claudia Carvalhoschneider
- Function : Author
Hélène Champagne
- Function : Author
Joséphine Chapalain
- Function : Author
Hubert Chardon
- Function : Author
Pascal Chavanet
- Function : Author
Judith Ducruet
- Function : Author
Olivier Epaulard
- Function : Author
Marc Fabre
- Function : Author
Dominique Fasquelle
- Function : Author
Emmanuel Forestier
- Function : Author
Jean-Marc Galempoix
- Function : Author
Guillaume Gautier
- Function : Author
Claire Goulard de Curraize
- Function : Author
Alain Gracet
- Function : Author
Camélia Gubavu
- Function : Author
Jérôme Guinard
- Function : Author
Tarik Habet
- Function : Author
Aurélie Haudour
- Function : Author
Caroline Henry
- Function : Author
Cécile Hombrouckalet
- Function : Author
Céline Janssen
- Function : Author
Jean-Paul Kisteman
- Function : Author
Philippe Lanotte
- Function : Author
- PersonId : 747523
- IdHAL : philippe-lanotte
- ORCID : 0000-0002-9993-5548
Marie-Frédérique Lartigue
- Function : Author
- PersonId : 745711
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Claire Launois
- Function : Author
- PersonId : 774173
- ORCID : 0000-0003-1983-8834
Cécile Lebrun
- Function : Author
Laurence Legout
- Function : Author
Marion Levast
- Function : Author
Yannick Madoux
- Function : Author
Laurence Maulin
- Function : Author
Stéphanie Mestrallet
- Function : Author
Abdo Mohareb
- Function : Author
Joy Mootien
- Function : Author
Yohan Nguyen
- Function : Author
Franck Noel
- Function : Author
Maja Ogielska
- Function : Author
Agathe Ogier Desserrey
- Function : Author
Anne Paleau
- Function : Author
Simona Pavel
- Function : Author
André Pechinot
- Function : Author
Isabelle Pelloux
- Function : Author
Camille Petillon
- Function : Author
Hélène Petitprez
- Function : Author
Bianca Podac
- Function : Author
Jerome Poirot
- Function : Author
Bénédicte Ponceau
- Function : Author
Nathalie Prieur
- Function : Author
Christine Recule
- Function : Author
Orlando Saraceni
- Function : Author
Jacques Sartre
- Function : Author
Farid Sifaoui
- Function : Author
Catherine Simonin
- Function : Author
- PersonId : 808703
- ORCID : 0000-0002-9323-5356
Christophe Strady
- Function : Author
Charlotte Tellini
- Function : Author
Anthony Texier
- Function : Author
Maxime Thouvenin
- Function : Author
Anne Tixier
- Function : Author
Pauline Tremeaux
- Function : Author
Pascale Verger
- Function : Author
Jean-Pierre Verquin
- Function : Author
Virginie Vitrat
- Function : Author
Isabelle Vray
- Function : Author
Oana Zamfir
- Function : Author
Laure Zucchini
- Function : Author
Abstract
Purpose: Invasive pneumococcal disease (IPD) is responsible for substantial mortality and morbidity worldwide. We aimed to identify host and bacterial factors associated with 30-day mortality in 18-year-old patients hospitalized with IPD in France from 2013 to 2015.Methods: This study analyzed data collected from consecutives IPD cases included in two parallel multi-center cohort studies: COMBAT study (280 patients with pneumococcal community-acquired bacterial meningitis) and SIIP study (491 patients with non-meningitis IPD). Factors associated with 30-day mortality were identified using logistic regression.Results: Among the 771 enrolled patients (median age 66 years, IQR [52.0-79.7]), 592/767 (77.2%) had at least one chronic disease. Patients with meningitis were younger (60.2 vs 70.9 years; p < 0.001) and had fewer chronic diseases than those with non-meningitis IPD (73.3% vs 79.4%; p = 0.05). Non-vaccine serotypes were more frequent in meningitis patients than in those with other IPD (36.1% vs 23.1%; p < 0.001). The overall 30-day mortality was 16.7% and patients with concurrent meningitis and extra-cerebral IPD had the highest 30-day mortality rate (26.5%). On multivariate analyses, older age, history of malignant solid tumor, meningeal IPD and serotypes previously identified with high mortality potential were independently associated with 30-day mortality. Of the serotypes with high mortality potential, 80% were included in licensed (PCV13 or PPV23) vaccines.Conclusion: We observed an effect of both host factors and pneumococcal serotypes on 30-day mortality in IPD. This highlights the need for a focused strategy to vaccinate at-risk patients.Clinical trial: ClinicalTrial. Gov identification number: NCT01730690.